Methods Development

The MLC contributes to the development of new techniques and research methods in areas such as animal husbandry and welfare, phenotyping of mutant lines, and mouse pathology. We are also at the forefront of improvements to technologies such as CRISPR and the latest imaging techniques.

Sectioning and Counting of Motor Neurons in the L3 to L6 Region of the Adult Mouse Spinal Cord

Austin, A., Beresford, L., Price, G., Cunningham, T., Kalmar, B., Yon, M.

(2022) , Curr Protoc , 2 , e428

10.1002/cpz1.428

35617451

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A guide to post-mortem examination procedure in mouse models

Rodrigues, A., Beresford, L., Scudamore, C. L., Yon, M.

(2022) , Lab Anim , , 236772221080827

10.1177/00236772221080827

35360986

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Universal Southern blot protocol with cold or radioactive probes for the validation of alleles obtained by homologous recombination

Codner, G. F., Erbs, V., Loeffler, J., Chessum, L., Caulder, A., Jullien, N., Wells, S., Birling, M. C., and Teboul, L

(2020) , Methods , 191 , 59-67

10.1016/j.ymeth.2020.06.011

32599056

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The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities

Herbert, E., Stewart, M., Hutchison, M., Flenniken, A. M., Qu, D., Nutter, L. M. J., McKerlie, C., Hobson, L., Kick, B., Lyons, B., Wieg, J. P., Doty, R., Aguilar-Pimentel, J. A., Hrabe de Angelis, M., Dickinson, M., Seavitt, J., White, J. K., Scudamore, C. L., Wells, S.

(2020) , PLoS One , 15 , e0230162

10.1371/journal.pone.0230162

PMC7295225

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Targeted Mutations in the Mouse via Embryonic Stem Cells

Gertsenstein, M., Mianne, J., Teboul, L., Nutter, L. M. J.

(2020) , Methods Mol Biol , 2066 , 59-82

10.1007/978-1-4939-9837-1_5

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