Methods Development

The MLC contributes to the development of new techniques and research methods in areas such as animal husbandry and welfare, phenotyping of mutant lines, and mouse pathology. We are also at the forefront of improvements to technologies such as CRISPR and the latest imaging techniques.

Universal Southern blot protocol with cold or radioactive probes for the validation of alleles obtained by homologous recombination

Codner, G. F., Erbs, V., Loeffler, J., Chessum, L., Caulder, A., Jullien, N., Wells, S., Birling, M. C., and Teboul, L

(2020) , Methods , 191 , 59-67



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The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities

Herbert, E., Stewart, M., Hutchison, M., Flenniken, A. M., Qu, D., Nutter, L. M. J., McKerlie, C., Hobson, L., Kick, B., Lyons, B., Wieg, J. P., Doty, R., Aguilar-Pimentel, J. A., Hrabe de Angelis, M., Dickinson, M., Seavitt, J., White, J. K., Scudamore, C. L., Wells, S.

(2020) , PLoS One , 15 , e0230162



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Targeted Mutations in the Mouse via Embryonic Stem Cells

Gertsenstein, M., Mianne, J., Teboul, L., Nutter, L. M. J.

(2020) , Methods Mol Biol , 2066 , 59-82


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Phenotyping in Mice Using Continuous Home Cage Monitoring and Ultrasonic Vocalization Recordings

Hobson, L., Bains, R. S., Greenaway, S., Wells, S., Nolan, P. M.

(2020) , Curr Protoc Mouse Biol , 10 , e80



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Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density

Swan, A. L., Schütt, C., Rozman, J., Del Mar Muñiz Moreno, M., Brmaier, S., Simon, M., Leuchtenberger, S., Griffiths, M., Brommage, R., Keskivali-Bond, P., Grallert, H., Werner, T., Teperino, R., Becker, L., Miller, G., Moshiri, A., Seavitt, J. R., Cissell, D. D., Meehan, T. F., Acar, E. F., Lelliott, C. J., Flenniken, A. M., Champy, M. F., Sorg, T., Ayadi, A., Braun, R. E., Cater, H., Dickinson, M. E., Flicek, P., Gallegos, J., Ghirardello, E. J., Heaney, J. D., Jacquot, S., Lally, C., Logan, J. G., Teboul, L., Mason, J., Spielmann, N., McKerlie, C., Murray, S. A., Nutter, L. M. J., Odfalk, K. F., Parkinson, H., Prochazka, J., Reynolds, C. L., Selloum, M., Spoutil, F., Svenson, K. L., Vales, T. S., Wells, S. E., White, J. K., Sedlacek, R., Wurst, W., Lloyd, K. C. K., Croucher, P. I., Fuchs, H., Williams, G. R., Bassett, D., Gailus-Durner, V., Herault, Y., Mallon, A. M., Brown, S. D. M., Mayer-Kuckuk, P., Hrabe de Angelis, M.

(2020) , PLoS Genet , 16 , e1009190


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