Methods Development
The MLC contributes to the development of new techniques and research methods in areas such as animal husbandry and welfare, phenotyping of mutant lines, and mouse pathology. We are also at the forefront of improvements to technologies such as CRISPR and the latest imaging techniques.
High-throughput mouse phenomics for characterizing mammalian gene function
Brown, S. D. M., Holmes, C. C., Mallon, A. M., Meehan, T. F., Smedley, D., Wells, S.
CRISPR-Cas9-Mediated Mutagenesis: Mind the Gap?
Teboul, L., Greenfield, A.
Assessing mouse behaviour throughout the light/dark cycle using automated in-cage analysis tools
Bains, R. S., Wells, S., Sillito, R. R., Armstrong, J. D., Cater, H. L., Banks, G., Nolan, P. M.
Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants
Codner, G. F., Mianne, J., Caulder, A., Loeffler, J., Fell, R., King, R., Allan, A. J., Mackenzie, M., Pike, F. J., McCabe, C. V., Christou, S., Joynson, S., Hutchison, M., Stewart, M. E., Kumar, S., Simon, M. M., Agius, L., Anstee, Q. M., Volynski, K. E., Kullmann, D. M., Wells, S., Teboul, L.
The trouble with collective nouns for genome editing
Wells, S., Joly, J. S.