Methods Development

The MLC contributes to the development of new techniques and research methods in areas such as animal husbandry and welfare, phenotyping of mutant lines, and mouse pathology. We are also at the forefront of improvements to technologies such as CRISPR and the latest imaging techniques.

High-throughput mouse phenomics for characterizing mammalian gene function

Brown, S. D. M., Holmes, C. C., Mallon, A. M., Meehan, T. F., Smedley, D., Wells, S.

(2018) , Nat Rev Genet , 19 , 357-370


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CRISPR-Cas9-Mediated Mutagenesis: Mind the Gap?

Teboul, L., Greenfield, A.

(2018) , The CRISPR Journal , 1 , 263-264


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Assessing mouse behaviour throughout the light/dark cycle using automated in-cage analysis tools

Bains, R. S., Wells, S., Sillito, R. R., Armstrong, J. D., Cater, H. L., Banks, G., Nolan, P. M.

(2018) , J Neurosci Methods , 300 , 37-47


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Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants

Codner, G. F., Mianne, J., Caulder, A., Loeffler, J., Fell, R., King, R., Allan, A. J., Mackenzie, M., Pike, F. J., McCabe, C. V., Christou, S., Joynson, S., Hutchison, M., Stewart, M. E., Kumar, S., Simon, M. M., Agius, L., Anstee, Q. M., Volynski, K. E., Kullmann, D. M., Wells, S., Teboul, L.

(2018) , BMC Biol , 16 , 70



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The trouble with collective nouns for genome editing

Wells, S., Joly, J. S.

(2017) , Mamm Genome , 28 , 365-366


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