Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43
Godoy-Corchuelo, J. M., Ali, Z., Brito Armas, J. M., Martins-Bach, A. B., García-Toledo, I., Fernández-Beltrán, L. C., López-Carbonero, J. I., Bascuñana, P., Spring, S., Jimenez-Coca, I., Muñoz de Bustillo Alfaro, R. A., Sánchez-Barrena, M. J., Nair, R. R., Nieman, B. J., Lerch, J. P., Miller, K. L., Ozdinler, H. P., Fisher, E. M. C., Cunningham, T. J., Acevedo-Arozena, A., Corrochano, S.
PKD1L1 Is Involved in Congenital Chylothorax
Whitchurch, J. B., Schneider, S., Hilger, A. C., Köllges, R., Stegmann, J. D., Waffenschmidt, L., Dyer, L., Thiele, H., Dhabhai, B., Dakal, T. C., Müller, A., Norris, D. P., Reutter, H. M.
Mutant Tbl1x male mice have a short lifespan and do not breed: unexpected findings
Hu, Y., Codner, G. F., Stewart, M., La Fleur, S. E., van Trotsenburg, P. A., Fliers, E., Hennekam, R. C., Boelen, A.
Leptin haploinsufficiency exerts sex-dependent partial protection in SOD1(G93A) mice by reducing inflammatory pathways in the adipose tissue
Fernández-Beltrán, L. C., Ali, Z., Larrad-Sanz, A., Lopez-Carbonero, J. I., Godoy-Corchuelo, J. M., Jimenez-Coca, I., Garcia-Toledo, I., Bentley, L., Gomez-Pinedo, U., Matias-Guiu, J. A., Gil-Moreno, M. J., Matias-Guiu, J., Corrochano, S.
TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system
Akula, S. K., Marciano, J. H., Lim, Y., Exposito-Alonso, D., Hylton, N. K., Hwang, G. H., Neil, J. E., Dominado, N., Bunton-Stasyshyn, R. K., Song, J. H. T., Talukdar, M., Schmid, A., Teboul, L., Mo, A., Shin, T., Finander, B., Beck, S. G., Yeh, R. C., Otani, A., Qian, X., DeGennaro, E. M., Alkuraya, F. S., Maddirevula, S., Cascino, G. D., Giannini, C., Burrage, L. C., Rosenfield, J. A., Ketkar, S., Clark, G. D., Bacino, C., Lewis, R. A., Segal, R. A., Bazan, J. F., Smith, K. A., Golden, J. A., Cho, G., Walsh, C. A.