Research supported by MLC

The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.

Tissue Proteome of 2-Hydroxyacyl-CoA Lyase Deficient Mice Reveals Peroxisome Proliferation and Activation of ω-Oxidation

Khalil, Y., Carrino, S., Lin, F., Ferlin, A., Lad, H. V., Mazzacuva, F., Falcone, S., Rivers, N., Banks, G., Concas, D., Aguilar, C., Haynes, A. R., Blease, A., Nicol, T., Al-Shawi, R., Heywood, W., Potter, P., Mills, K., Gale, D. P., Clayton, P. T.

(2022) , Int J Mol Sci , 23 , 987

10.3390/ijms23020987

PMC8781152

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Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing

Newton, S., Kong, F., Carlton, A. J., Aguilar, C., Parker, A., Codner, G. F., Teboul, L., Wells, S., Brown, S. D. M., Marcotti, W., Bowl, M. R.

(2022) , PLoS Genet , 18 , e1009937

10.1371/journal.pgen.1009937

PMC8830789

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Identifying genetic determinants of inflammatory pain in mice using a large-scale gene-targeted screen

Wotton, J. M., Peterson, E., Flenniken, A. M., Bains, R. S., Veeraragavan, S., Bower, L. R., Bubier, J. A., Parisien, M., Bezginov, A., Haselimashhadi, H., Mason, J., Moore, M. A., Stewart, M. E., Clary, D. A., Delbarre, D. J., Anderson, L. C., D'Souza, A., Goodwin, L. O., Harrison, M. E., Huang, Z., McKay, M., Qu, D., Santos, L., Srinivasan, S., Urban, R., Vukobradovic, I., Ward, C. S., Willett, A. M., Braun, R. E., Brown, S. D. M., Dickinson, M. E., Heaney, J. D., Kumar, V., Lloyd, K. C. K., Mallon, A. M., McKerlie, C., Murray, S. A., Nutter, L. M. J., Parkinson, H., Seavitt, J. R., Wells, S., Samaco, R. C., Chesler, E. J., Smedley, D., Diatchenko, L., Baumbauer, K. M., Young, E. E., Bonin, R. P., Mandillo, S., White, J. K.

(2022) , Pain , 163 , 1139-1157

10.1097/j.pain.0000000000002481

PMC9100450

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Gadd45g is required for timely Sry expression independently of RSPO1 activity

Warr, N., Siggers, P., May, J., Chalon, N., Pope, M., Wells, S., Chaboissier, M. C., Greenfield, A.

(2022) , Reproduction , 163 , 333-340

10.1530/rep-21-0443

PMC9066659

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Biallelic DAW1 variants cause a motile ciliopathy characterized by laterality defects and subtle ciliary beating abnormalities

Leslie, J. S., Hjeij, R., Vivante, A., Bearce, E. A., Dyer, L., Wang, J., Rawlins, L., Kennedy, J., Ubeyratna, N., Fasham, J., Irons, Z. H., Craig, S. B., Koenig, J., George, S., Pode-Shakked, B., Bolkier, Y., Barel, O., Mane, S., Frederiksen, K. K., Wenger, O., Scott, E., Cross, H. E., Lorentzen, E., Norris, D. P., Anikster, Y., Omran, H., Grimes, D. T., Crosby, A. H., Baple, E. L.,

(2022) , Genet Med , ,

10.1016/j.gim.2022.07.019

36074124

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