Research supported by MLC

The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.

Tissue Proteome of 2-Hydroxyacyl-CoA Lyase Deficient Mice Reveals Peroxisome Proliferation and Activation of ω-Oxidation

Khalil, Y., Carrino, S., Lin, F., Ferlin, A., Lad, H. V., Mazzacuva, F., Falcone, S., Rivers, N., Banks, G., Concas, D., Aguilar, C., Haynes, A. R., Blease, A., Nicol, T., Al-Shawi, R., Heywood, W., Potter, P., Mills, K., Gale, D. P., Clayton, P. T.

(2022) , Int J Mol Sci , 23 , 987



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Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing

Newton, S., Kong, F., Carlton, A. J., Aguilar, C., Parker, A., Codner, G. F., Teboul, L., Wells, S., Brown, S. D. M., Marcotti, W., Bowl, M. R.

(2022) , PLoS Genet , 18 , e1009937



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Identifying genetic determinants of inflammatory pain in mice using a large-scale gene-targeted screen

Wotton, J. M., Peterson, E., Flenniken, A. M., Bains, R. S., Veeraragavan, S., Bower, L. R., Bubier, J. A., Parisien, M., Bezginov, A., Haselimashhadi, H., Mason, J., Moore, M. A., Stewart, M. E., Clary, D. A., Delbarre, D. J., Anderson, L. C., D'Souza, A., Goodwin, L. O., Harrison, M. E., Huang, Z., McKay, M., Qu, D., Santos, L., Srinivasan, S., Urban, R., Vukobradovic, I., Ward, C. S., Willett, A. M., Braun, R. E., Brown, S. D. M., Dickinson, M. E., Heaney, J. D., Kumar, V., Lloyd, K. C. K., Mallon, A. M., McKerlie, C., Murray, S. A., Nutter, L. M. J., Parkinson, H., Seavitt, J. R., Wells, S., Samaco, R. C., Chesler, E. J., Smedley, D., Diatchenko, L., Baumbauer, K. M., Young, E. E., Bonin, R. P., Mandillo, S., White, J. K.

(2022) , Pain , 163 , 1139-1157



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Gadd45g is required for timely Sry expression independently of RSPO1 activity

Warr, N., Siggers, P., May, J., Chalon, N., Pope, M., Wells, S., Chaboissier, M. C., Greenfield, A.

(2022) , Reproduction , 163 , 333-340



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Biallelic DAW1 variants cause a motile ciliopathy characterized by laterality defects and subtle ciliary beating abnormalities

Leslie, J. S., Hjeij, R., Vivante, A., Bearce, E. A., Dyer, L., Wang, J., Rawlins, L., Kennedy, J., Ubeyratna, N., Fasham, J., Irons, Z. H., Craig, S. B., Koenig, J., George, S., Pode-Shakked, B., Bolkier, Y., Barel, O., Mane, S., Frederiksen, K. K., Wenger, O., Scott, E., Cross, H. E., Lorentzen, E., Norris, D. P., Anikster, Y., Omran, H., Grimes, D. T., Crosby, A. H., Baple, E. L.,

(2022) , Genet Med , ,



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