Research supported by MLC
The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.
TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system
Akula, S. K., Marciano, J. H., Lim, Y., Exposito-Alonso, D., Hylton, N. K., Hwang, G. H., Neil, J. E., Dominado, N., Bunton-Stasyshyn, R. K., Song, J. H. T., Talukdar, M., Schmid, A., Teboul, L., Mo, A., Shin, T., Finander, B., Beck, S. G., Yeh, R. C., Otani, A., Qian, X., DeGennaro, E. M., Alkuraya, F. S., Maddirevula, S., Cascino, G. D., Giannini, C., Burrage, L. C., Rosenfield, J. A., Ketkar, S., Clark, G. D., Bacino, C., Lewis, R. A., Segal, R. A., Bazan, J. F., Smith, K. A., Golden, J. A., Cho, G., Walsh, C. A.
Tissue specific differences in the assembly of mitochondrial complex I is revealed by a novel ENU mutation in ECSIT
Nicol, T. Falcone, S. Blease, A. Vikhe, P. Civiletto, G. Omairi, S. S. Viscomi, C. Patel, K. Potter, P. K.
Genome-wide screening reveals the genetic basis of mammalian embryonic eye development
Chee, J. M., Lanoue, L., Clary, D., Higgins, K., Bower, L., Flenniken, A., Guo, R., Adams, D. J., Bosch, F., Braun, R. E., Brown, S. D. M., Chin, H. G., Dickinson, M. E., Hsu, C. W., Dobbie, M., Gao, X., Galande, S., Grobler, A., Heaney, J. D., Herault, Y., de Angelis, M. H., Mammano, F., Nutter, L. M. J., Parkinson, H., Qin, C., Shiroishi, T., Sedlacek, R., Seong, J. K., Xu, Y., Brooks, B., McKerlie, C., Lloyd, K. C. K., Westerberg, H., Moshiri, A.
Dynamic modulation of genomic enhancer elements in the suprachiasmatic nucleus, the site of the mammalian circadian clock
Bafna, A., Banks, G., Hastings, M. H., Nolan, P. M.
Cysteine-lowering treatment with mesna against obesity: Proof of concept and results from a human phase I, dose-finding study
Vinknes, K. J. Olsen, T. Zare, H. K. Bastani, N. E. Stolt, E. Dahl, A. F. Cox, R. D. Refsum, H. Retterstol, K. Asberg, A. Elshorbagy, A.