Research supported by MLC

The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.

Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring

Gaspar, R. S., Unsworth, A. J., Al-Dibouni, A., Bye, A. P., Sage, T., Stewart, M., Wells, S., Cox, R. D., Gibbins, J. M., Sellayah, D., C, E. Hughes

(2021) , Sci Rep , 11 , 1473

10.1038/s41598-020-80373-3

PMC7809045

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Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis

Muha, V., Authier, F., Szoke-Kovacs, Z., Johnson, S., Gallagher, J., McNeilly, A., McCrimmon, R. J., Teboul, L., van Aalten, D. M. F.

(2021) , J Biol Chem , 296 , 100439

10.1016/j.jbc.2021.100439

PMC7988489

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Ap2s1 mutation causes hypercalcaemia in mice and impairs interaction between calcium-sensing receptor and adaptor protein-2

Hannan, F. M., Stevenson, M., Bayliss, A. L., Stokes, V. J., Stewart, M., Kooblall, K. G., Gorvin, C. M., Codner, G., Teboul, L., Wells, S., Thakker, R. V.

(2021) , Hum Mol Genet , 30 , 880-892

10.1093/hmg/ddab076

PMC8165646

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A novel knockout mouse for the small EDRK-rich factor 2 (Serf2) showing developmental and other deficits

Cleverley, K., Lee, W. C., Mumford, P., Collins, T., Rickman, M., Cunningham, T. J., Cleak, J., Mianne, J., Szoke-Kovacs, Z., Stewart, M., Teboul, L., Maduro, C., Wells, S., Wiseman, F. K., Fisher, E. M. C.

(2021) , Mamm Genome , 32 , 94-103

10.1007/s00335-021-09864-6

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Studies of mice deleted for Sox3 and uc482: relevance to X-linked hypoparathyroidism

Gaynor, K. U., Grigorieva, I. V., Mirczuk, S. M., Piret, S., Kooblall, K. G., Stevenson, M., Rizzoti, K., Bowl, M. R., Nesbit, M. A., Christie, P. T., Fraser, W. D., Hough, T., Whyte, M. P., Lovell-Badge, R., Thakker, R.

(2020) , Endocr Connect , 9 , 173-186

10.1530/ec-19-0478

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