
Advanced Mouse Genetics
This course explores more complex genetics topics, including multiple allele crosses, complex disease models and will inform breeding strategies and experimental design rather than give a complete guide to the molecular biology. Our team of experienced trainers will support you to examine how different modification lead to different breeding strategies, the importance of genetic consistency and integrity, different modes of inheritance and troubleshooting of reproducibility.
Who is this for?
- Senior animal technicians
- Colony managers
- Researchers
After the course, you will be able to:
- Understand the foundations of mouse genetics and its use in biomedical research
- Have a working knowledge of the genetic background of mouse strains
- Understand how to maintain the genetic integrity of inbred lines
- Predict the outcomes of genetic crosses involving multiple alleles
- Understand the fundamentals of different methods that give rise to Genetically Altered mice strains
- Understand how Genetically Altered lines can be established from modern transgenic technologies
- Troubleshoot breeding and colony maintenance issues
- Nomenclature and access to international mouse resources
Hourly Schedule
Day 1
- 10:00 - 10:30
- Introductions
- Registration, Orientation, Coffee, Icebreaker and H&S
- 10:30 - 11:30
- Session 1
- Inbred strains, genetic drift and diversity in mouse strains
- 11:30 - 12:15
- Session 2
- Multiple allele inheritance
- 12:15 - 13:00
- Lunch
- Lunch is provided
- 13:00 - 13:30
- Session 3
- Chromosomal linkage, GxE
- 13:30 - 14:30
- Session 4
- Generating GA mice
- 14:30 - 14:50
- Break
- Refreshments provided
- 14:50 - 16:00
- Session 5
- Nomenclature, backcrossing, viability statistics
Day 2
- 09:30 - 10:30
- Session 1
- Maintaining GA lines. Colony calculations.
- 10:30 - 11:00
- Session 2
- Complex cohort breeding
- 11:00 - 12:15
- Session 3
- Breeding workshops and discussions
- 12:15 - 13:00
- Lunch
- Lunch is provided
- 13:00 - 13:45
- Session 4
- Randomisation and blinding
- 13:45 - 14:45
- Session 5
- Troubleshooting breeding colony maintenance issues
- 14:45 - 16:00
- Session 6
- Nomenclature and accessing international mouse resources. Course end.