Generation of mouse mutants by genome editing
Depending on your needs, we generate new mouse models using CRISPR/Cas9 and electroporation of 0.5 day-old embryos.
We generate models according to your specifications or can advise on designs that are suitable for your project.
We plan modifications so they address biological question and permit straight forward genotyping with the technologies that are available to you at the point of colony maintenance.
New alleles are validated by sequencing of the region of interest and additional random integrations of donors or deleted segments are checked against by copy counting.
Please use the contact form to find out about mouse model generation services at the Mary Lyon Centre.