Research supported by MLC

The MLC supports the work of many research groups across a diverse range of disease areas, including hearing loss, type 2 diabetes, sex determination, neurodegeneration and circadian function, to name a few. Such support can include detailed phenotyping in addition to generation and husbandry of mutant mouse lines.

Genome-wide screening reveals the genetic basis of mammalian embryonic eye development

Chee, J. M., Lanoue, L., Clary, D., Higgins, K., Bower, L., Flenniken, A., Guo, R., Adams, D. J., Bosch, F., Braun, R. E., Brown, S. D. M., Chin, H. G., Dickinson, M. E., Hsu, C. W., Dobbie, M., Gao, X., Galande, S., Grobler, A., Heaney, J. D., Herault, Y., de Angelis, M. H., Mammano, F., Nutter, L. M. J., Parkinson, H., Qin, C., Shiroishi, T., Sedlacek, R., Seong, J. K., Xu, Y., Brooks, B., McKerlie, C., Lloyd, K. C. K., Westerberg, H., Moshiri, A.

(2023) , BMC Biol , 21 , 22



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Dynamic modulation of genomic enhancer elements in the suprachiasmatic nucleus, the site of the mammalian circadian clock

Bafna, A., Banks, G., Hastings, M. H., Nolan, P. M.

(2023) , Genome Res , 33 , 673-688



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Cysteine-lowering treatment with mesna against obesity: Proof of concept and results from a human phase I, dose-finding study

Vinknes, K. J. Olsen, T. Zare, H. K. Bastani, N. E. Stolt, E. Dahl, A. F. Cox, R. D. Refsum, H. Retterstol, K. Asberg, A. Elshorbagy, A.

(2023) , Diabetes Obes Metab , 25 , 3161-3170



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Cleft palate and minor metabolic disturbances in a mouse global Arl15 gene knockout

Bai, Y., Bentley, L., Ma, C., Naveenan, N., Cleak, J., Wu, Y., Simon, M. M., Westerberg, H., Cañas, R. C., Horner, N., Pandey, R., Paphiti, K., Schulze, U., Mianné, J., Hough, T., Teboul, L., de Baaij, J. H. F., Cox, R. D.

(2023) , FASEB J , 37 , e23211



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Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6

Jones, E., Hill, E., Linehan, J., Nazari, T., Caulder, A., Codner, G. F., Hutchison, M., Mackenzie, M., Farmer, M., Coysh, T., De Oliveira, M. W., Al-Doujaily, H., Sandberg, M., Viré, E., Cunningham, T. J., Asante, E. A., Brandner, S., Collinge, J., Mead, S.

(2023) , Neurobiol Dis , 190 , 106363



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